Does having Turner syndrome affect quality of life in Brazilian women compared to common population?

ABSTRACT Objectives We aimed to measure the quality of life (QoL) of patients with Turner syndrome (PTS) and determine the extent to which their clinical or laboratory alterations influence QoL compared to reference women (RW) of the same age range. Subjects and methods From Dec-2013 to Dec-2014, 90 participants were recruited. They were 18 years and older: 48 with Turner syndrome (TS) (PTS) and 42 without (RW). Recruited subjects completed the Portuguese version of Short Form 36 (SF-36) questionnaire, and blood was drawn to measure LH, FSH, oestradiol (E2), progesterone (P4), SHBG, and SDHEA (by ECLIA) and testosterone (by LC MS/MS). Results Age and schooling were similar between groups. The most common occupations for PTS were health worker, administration and education, and health worker or cashier for RW. Most participants were Catholic or Evangelical. Eighty-one percent (39/48) of cases used Hormonal Replacement Therapy (HRT), mostly transdermal (23/39). RW and PTS scored similarly on the SF-36 questionnaire. RW had higher oestradiol (p = 0,01), lower FSH (p = 0,01) and higher testosterone (p = 0,01) than PTS. Concentrations of P4, LH, SHBG or SDHEA were similar. Significant associations were found among QoL and hormones (E2 with Vitality and LH with Physical Role) only in the PTS group. Conclusions PTS do not consider that TS affects their QoL as measured by domains on the SF-36. Oestradiol was related with QoL, emphasising the importance of HRT.

Papel da vasopressina no ritmo de pressäo arterial em pacientes diabéticos portadores de neuripatia autonômica avançada / Role of vassopressin on 24-h blood pressure regulation in diabetics with severe autonomic neuropathy

RESUMO - I INFLUÊNCIA DA NEUROPATIA AUTONÔMICA NA DISFUNÇÃO DO VENTRÍCULO ESQUERDO EM DIABÉTICOS INSULINO DEPENDENTES Neste estudo foram analisadas as interrelações entre neuropatia autonômica (NA), o ritmo da pressão arterial (PA) e a disfunção ventricular esquerda em pacientes diabéticos do tipo 1. Dezenove pacientes foram submetidos aos testes para avaliação de neuropatia autonômica, à monitorização ambulatorial da PA por 24 horas e realizaram um ecocardiograma. Os pacientes foram então divididos pela presença (NA+) ou não (NA-) de NA. No grupo NA+ (n=8), a razão E/A ao ecocardiograma foi menor que no grupo NA - (n=11) (1,1ñ0,3 vs. 1,6ñ0,3; p

Microangiopathic complications in type 1 diabetes mellitus: differences in severity when isolated or associated with autoimmune polyendocrinopathies

Context: The development and evolution of different chronic diabetic complications may present variations among the different types and conditions of this disease. Objective: To evaluate the degree of microangiopathy in Type 1 diabetes mellitus (DM1) associated with autoimmune polyendocrinopathies (OSAD) or isolated DM1 (iDM1). Patients: OSAD (n=17)and iDM1 (n=13) were over 15 years old at diagnosis of DM and were matched for diabetes duration (13.9 + 8.2 and 13.2 + 5.9 years, respectively) and metabolic control (HbA1c: 6.4 + 1.9 and 6.8 + 1.4 per cent). Main Outcome Measures: Urinary albumin excretion (UAE; ELISA), the inversion of serum creatinine (1/C) level and indirect ophthalmoscopy. Results: Although the prevalence of hypertension was similar in both groups, the OSAD had inferior levels of UAE (7.4 + 2.5 vs. 17.3 + 9.2 mug/min; p<0.05). Nephropathy was detected in 12 per cent of the OSAD (none of them macroproteinuric) and in 39 per cent of the iDM1. The UAE in the iDM1 correlated negatively with 1/C values (r= -0.7, p<0.005), but the same did not occur in the OSAD (r= 0.2, ns). Among patients with retinopathy, the severe form was found in 29 per cent of the OSAD and in 46 per cent of the iDM1. Conclusions. OSAD was associated with a lower degree of microangiopathy, in spite of age at diagnosis, duration of diabetes and the metabolic control. In contrast with the iDM1, the increase in UAE of OSAD was not associated with reductions in GFR.